Predicted template modelling score (pTM)
pTM is defined as a measure of the accuracy of the global structure of the protein and is relatively insensitive to localised inaccuracies (Xu and Zhang, 2010).
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pTM is defined as a measure of the accuracy of the global structure of the protein and is relatively insensitive to localised inaccuracies (Xu and Zhang, 2010).
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Predicted template modelling score (pTM) is an integrated measure of how well AlphaFold-Multimer/Monomer and Boltz has predicted the structure of a complex. It is the predicted template modelling (TM) score for a superposition between the predicted structure and the hypothetical true structure. pTM scores vary between 0 and 1: a score above 0.5 means the overall predicted fold for the complex will be similar to the true structure.
A TM score below 0.5 means the predicted structure is likely wrong: pTM score follows the same definition. pTM score should be interpreted cautiously. For example, imagine a situation where one of the interacting proteins is larger, and its structure is predicted correctly, while a smaller partner protein is predicted incorrectly. The resulting pTM score of the complex could be dominated by the larger protein and show a pTM score above 0.5.
